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Primary amines also allow installation of pH-sensitive (e.g., imine, hydrazone) or redox-sensitive (e.g., disulfide) linkages that remain stable in blood but cleave in the acidic, reducing TME triggering payload release precisely where it is needed
Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling
This increases the risk of hormone imbalance, mood disorders, liver damage, and other related side effects
To compare the nominal covariates with the outcome GSH levels, the Students t -test or analysis of variance (ANOVA) was used
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